mercredi 28 septembre 2016

mardi 27 septembre 2016

A nuclear bomb just sent to Big Pharma

http://opentrials.net/2016/08/10/opentrialsfda-unlocking-the-trove-of-clinical-trial-data-in-drugsfda/


Aux sources du plan de métissage forcé de l'Europe: quand un "noble" confond consanguinité et métissage hors éco-niche...

https://archive.org/details/R.N.CoudenhoveKalergiIdealismePratique1925FR

Violence de certains patients: le phénomène s'aggrave à cause du laxisme et d'une réponse inappropriée

Sidéré par le titre. Le Fig est au plus mal.
Les hôpitaux français: 
gangrénés par la violence des patients,
victimes de la violence des patients,
sans réponse devant l'accroissement de la violence des patients
la violence de certains patients entrave le fonctionnement des hôpitaux etc

http://www.lefigaro.fr/actualite-france/2016/09/26/01016-20160926ARTFIG00349-les-hopitaux-francais-malades-de-la-violence.php



Mais le pompom est décerné sans conteste à C Prudhomme:
Christophe Prudhomme est porte-parole de l'Association des médecins urgentistes de France (Amuf). Il travaille au Samu de Bobigny. Pour lui, le problème vient en partie du trop grand nombre de patients arrivant aux urgences, du fait du manque de généralistes: «Comme nos collègues médecins de ville sont débordés, les malades se retrouvent à l'hôpital, aux urgences» . Selon, lui, «il faut former le personnel hospitalier à la gestion de la violence, lui apprendre la médiation, la contention physique, que ce soit pour des patients agressifs ou pour des malades plus psychiatriques. Il existe des techniques pour faire baisser le seuil d'agressivité».

Du politiquement correct bien ciselé du Valls pur jus. Faut vous y faire bande de blancos.

dimanche 25 septembre 2016

An erroneous analysis on France Economics

http://www.lopinion.fr/edition/politique/erwan-noan-pourquoi-l-etat-croit-il-110686

How government policies could harm productivity in the aftermaths of the recession.

https://www.fiscalcommission.gov/sites/fiscalcommission.gov/files/documents/TheMomentofTruth12_1_2010.pdf


http://www.wsj.com/articles/the-reasons-behind-the-obama-non-recovery-1474412963


http://www.aei.org/multimedia/an-army-of-jobless-men/?utm_source=paramount&utm_medium=email&utm_content=AEITHISWEEK&utm_campaign=Weekly092416

"It wasn’t the severity of the Great Recession that caused the weak recovery, but government policies."
Robert J. BARRO
"The main U.S. policy used to counter the Great Recession was increased government transfer payments. Federal social benefits to persons as a ratio to GDP went from 8.7% in 2007 to 11.7% in 2010, then fell to 10.9% in 2015. The main increases applied to Medicaid, Medicare, Social Security (including disability) and food stamps, whereas unemployment insurance first rose then fell. Unfortunately, increased transfer payments do not promote productivity growth."

"The 2007-08 financial crisis was also followed by vast monetary expansion involving increases in the balance sheets of the Federal Reserve and other central banks. The Fed’s expansion featured a dramatic rise in excess reserves, used to fund increased holdings of Treasury bonds and mortgage-backed securities. Remarkably, the strong monetary growth came without inflation."

"The absence of inflation is surprising but may have occurred because weak opportunities for private investment motivated banks and other institutions to hold the Fed’s added obligations despite the negative real interest rates paid. In this scenario, the key factor is the flight to quality stimulated by the heightened perceived risk in private investment."

Doses it look like something we experienced in France? Yes.

vendredi 23 septembre 2016

Is glucose lowering efficient for CV events prevention in D2 patients?

Table 1. Major CVOTs With Glucose Lowering Medications in Patients With T2DM at High Risk of a CV Event
Trial NameAgent/
comparator
NPrimary
Endpoint
Follow-UpEnd of Trial HbA1c
(%)
Primary Outcome
HR
(95% CI)
ORIGINInsulin glargine/
conventional
12,5373-point MACE6.2 yearsInsulin 6.2
Control 6.5
Neutral
HR 1.02
(0.94 to 1.11)
SAVOR- TIMI 53Saxa

ts?gliptin/
placebo
16,4923-point MACE24 monthsSaxagliptin 7.7
Placebo 7.9
Neutral
HR 1.00
(0.89 to 1.12)
EXAMINEAlogliptin/ placebo53803-point MACE18 monthsAlogliptin 7.7
Placebo 8.0
Neutral
HR 0.96
(-1.16)
TECOSSitagliptin/
placebo
14,6714-point MACE36 monthsSitagliptin 7.1
Placebo 7.4
Neutral
HR 0.98
(0.99 to 1.08)
ELIXALixisenatide/
placebo
60684-point MACE25 monthsLixisenatide 7.4
Placebo 7.6
Neutral
HR 1.02
(0.89 to 1.17)
EMPA-REG OUTCOMEEmpagliflozin/
placebo
70203-point MACE37 monthsEmpagliflozin 7.8
Placebo 8.2
Superior to placebo
HR 0.86
(0.74 to 0.99)
LEADERLiraglutide/
placebo
93403-point MACE46 monthsLiraglutide 7.7
Placebo 8.1
Superior to placebo
HR 0.87
(0.78 to 0.97)
3-point MACE = composite of CV death and nonfatal MI or stroke; 4-point MACE = composite of CV death, nonfatal MI or stroke and hospitalization for unstable angina; CI = confidence interval; CVOT = cardiovascular outcomes trial; CV = cardiovascular; HbA1c = glycated hemoglobin; HR = hazard ratio; MI = myocardial infarction; T2DM = type 2 diabetes mellitus

Sources: Ryden L et al[3]; Sattar N, et al[4]; and Marso SP, et al.[15]

http://www.medscape.org/sites/conference/easd-2016?src=mkmcmr_conf_easd16_mscpedu_slides 

Les systèmes de soins dans l'OCDE sont peu efficients

indicateurs clés sur les systèmes de soins

mardi 20 septembre 2016

Milton Friedman

“The world runs on individuals pursuing their self interests. The great achievements of civilization have not come from government bureaus. Einstein didn’t construct his theory under order from a bureaucrat. Henry Ford didn’t revolutionize the automobile industry that way.”

Read more: http://thelibertarianrepublic.com/10-milton-friedman-quotes-that-will-make-liberal-heads-explode/2/#ixzz4KnPFOpgX 
Follow us: @TheLibRepublic on Twitter

Pilecki's story

 http://cosmopolitanreview.com/?s=Pilecki
The courage of Pilecki is nothing less than extraordinary

 
Paperblog